Acute and sub-acute oral toxicity of the methanol extract of Adansonia digitata fruit pulp.

Most rural and urban-based communities in Africa rely on traditional remedies for their primary healthcare. One probable reason this is the assumption that they are free of harmful side effects toxicity, compared to orthodox drugs. However, very few plants have been thoroughly evaluated toxic effects. Adansonia digitata (A. digitata) also known as (Baobab) a member Malvaceae family. Almost all components tree utilized African medicine. The present study potential toxicity methanol extract from fruit pulp through acute sub-acute oral administration rats. was done according Organization Economic Co-operation Development (OECD) guidelines no 425 using limit dose 2000 mg/kg body weight (BW). Sub-acute (250, 500, and, 1000 BW) performed by daily 28 days OECD guideline 407. revealed lethal behavioral signs at tested indicating LD greater than 2000mg/kg. In study, significant difference observed weight, organ liver, kidney parameters treated groups control. A non-significant decrease packed cell volume (PCV) across groups. Also, increase white blood count lymphocyte occurred group with 250 BW. These results show generally safe short-term use but can cause changes haematological long-term use.